L-4'-TETRAHYDROPYRANYLGLYCINE, CAS No. 811842-25-8

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811842-25-8

Catalog No. EBD2203839

CAS 811842-25-8

Name L-4'-TETRAHYDROPYRANYLGLYCINE

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Basic Information

Synonyms: 2H-Pyran-4-aceticacid,α-aminotetrahydro-,(αS)- L-4'-TETRAHYDROPYRANYLGLYCINE (s)-2-amino-2-(tetrahydro-2h-pyran-4-yl)aceticacid refdupl:l-4'-tetrahydropyranylglycine 2h-pyran-4-aceticacid,.alpha.-aminotetrahydro-,(.alpha.s)- (s)-a-aminotetrahydro-2h-pyran-4-aceticacid (2S)-amino(tetrahydro-2H-pyran-4-yl)ethanoicacid (2S)-Amino(tetrahydro-2H-pyran-4-yl)aceticacid 2H-pyran-4-aceticacid,alpha-aminotetrahydro-,(alphaS)-

Molecular Formula: C7H13NO3

Molecular Weight: 159.18

MDL Number: MFCD03419267

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

L-4'-Tetrahydropyranylglycine is a non-proteinogenic amino acid derivative characterized by a glycine backbone with a tetrahydropyranyl (THP) group attached to the alpha-amino nitrogen. This structural modification imparts unique steric and electronic properties, making it a valuable chiral building block in synthetic chemistry. Its primary application is in the field of pharmaceutical research and development, where it serves as a key intermediate in the synthesis of complex bioactive molecules. The THP-protected amino acid moiety is particularly useful in peptide mimetics and the construction of novel drug candidates, especially those targeting proteases or requiring constrained peptide backbones to enhance metabolic stability and bioavailability. This compound is utilized in the preparation of potential therapeutic agents and is a subject of study in medicinal chemistry for creating structurally diverse pharmacophores. As a specialty amino acid derivative, it falls under the category of fine chemicals used in advanced organic synthesis for life science applications.

Physical Properties

Boiling Point: 316.7 °C at 760 mmHg

Flash Point: 145.3 °C

Density: 1.211 g/cm3