FMOC-D-alanine, CAS No. 79990-15-1

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79990-15-1

Catalog No. EBD31000

CAS 79990-15-1

Name FMOC-D-alanine

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Basic Information

Synonyms: Fmoc-D-alanine Fmoc-D-Ala-OH*H2O Fmoc-D-Ala-OH NALPHA-9-Fluorenylmethoxycarbonyl-D-alanine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-alanine N-9-Fluorenylmethoxycarbonyl-D-alanine

Molecular Formula: C18H17NO4

Molecular Weight: 311.33

MDL Number: MFCD00062960

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Fmoc-D-alanine is a protected amino acid derivative, specifically the D-enantiomer of alanine with a 9-fluorenylmethoxycarbonyl (Fmoc) group protecting the amine functionality. Its CAS number is 79990-15-1. This compound is a white to off-white crystalline powder and is a fundamental building block in solid-phase peptide synthesis (SPPS) using the Fmoc strategy. Its primary and most significant application is in the pharmaceutical and life sciences research fields for the synthesis of peptides and peptidomimetics. The Fmoc group is base-labile, allowing for mild deprotection conditions, which is crucial for synthesizing complex and sensitive peptide sequences. D-amino acids, like D-alanine, are incorporated into peptides to enhance metabolic stability, alter biological activity, or induce specific conformational changes, making them valuable tools in drug discovery and development. As a readily available and standardized reagent, Fmoc-D-alanine is also a common organic synthesis building block, particularly for introducing chiral amine centers or alanine moieties into more complex molecular architectures beyond peptide synthesis. It is widely supplied by fine chemical and peptide synthesis reagent vendors.

Physical Properties

Melting Point: 151-155 °C

Boiling Point: 544.1 °C at 760 mmHg

Flash Point: 282.9 °C

Density: 1.282 g/cm3

Refractivity: 19 ° (C=1, DMF)

Storage: 2-8°C

Analytical Data

Appearance: white to off-white crystalline powder