(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride, CAS No. 79559-97-0

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79559-97-0

Catalog No. EBD9395

CAS 79559-97-0

Name (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride

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Basic Information

Synonyms: 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-aminehydrochloride(1:1) (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-aminehydrochloride SertralineHCL sertralinehydrochloride (1s,4s)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenaminehydrochloride

Molecular Formula: C17H18Cl3N

Molecular Weight: 342.69

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

Sertraline hydrochloride, with the CAS number 79559-97-0, is the hydrochloride salt of sertraline. It is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Chemically, it is designated as (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride, featuring a naphthalene core structure. This compound is the active pharmaceutical ingredient (API) in the widely prescribed antidepressant drug Zoloft. It functions by inhibiting the reuptake of serotonin in the brain, thereby increasing the extracellular levels of this neurotransmitter, which is associated with mood regulation. It is primarily used for the treatment of major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, and post-traumatic stress disorder. Sertraline hydrochloride is typically formulated into oral dosage forms such as tablets and oral concentrate solutions. As a key central nervous system drug, its synthesis, purity, and stability are critical parameters in pharmaceutical manufacturing, requiring strict adherence to pharmacopeial standards.

Physical Properties

Melting Point: 246-249°C

Boiling Point: 416.3 °C at 760 mmHg

Flash Point: 205.6 °C

Solubility: DMSO: ~26 mg/mL

Analytical Data

Appearance: White or white-like crystalline powder