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    78887-39-5

    Catalog No. EBD435777

    CAS 78887-39-5

    Name 3-Acetamidophenylboronicacid

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    Basic Information

    Synonyms: 3-Acetamidophenylboronicacid 3-Acetamidobenzeneboronicacid (3-Acetylaminophenyl)boronicacid

    Molecular Formula: C8H10BNO3

    Molecular Weight: 178.98

    MDL Number: MFCD00236013

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    3-Acetamidophenylboronic acid is an organic compound featuring both a boronic acid group and an acetamido substituent on a phenyl ring. It is a white to off-white crystalline powder with a molecular formula of C8H10BNO3. This compound is a versatile synthetic building block, primarily valued for its role in Suzuki-Miyaura cross-coupling reactions, a pivotal method for forming carbon-carbon bonds. Its primary industrial and research application is as a key intermediate in pharmaceutical synthesis. The boronic acid moiety enables efficient coupling with various aryl halides, while the acetamido group can serve as a protected aniline or be further functionalized. This makes it a crucial precursor in the development of active pharmaceutical ingredients (APIs), particularly for compounds containing biaryl or substituted aniline structures. It is frequently employed in the synthesis of drug candidates targeting various therapeutic areas. As a commercially available boronic acid derivative, it is a staple reagent in medicinal chemistry and process research. It should be stored in a cool, dry place, protected from moisture due to the sensitivity of the boronic acid group.
    Physical Properties

    Melting Point: 135 °C(lit.)

    Density: 1.23 g/cm3

    Storage: Refrigerator (+4°C)

    Analytical Data

    Appearance: off-white to pale brown powder

    mg g kg ml l t