(2-Amino-5-chlorophenyl)(2-fluorophenyl)methanone, CAS No. 784-38-3

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784-38-3

Catalog No. EBD49047

CAS 784-38-3

Name (2-Amino-5-chlorophenyl)(2-fluorophenyl)methanone

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Basic Information

Synonyms: 2-Amino-5-chloro-2'-fluorobenzophenone (2-Amino-5-Chloro-Phenyl)-(2-Fluoro-Phenyl)-Methanone 2-Amino-2'-Fluoro-5-Chlorobenzophenone Benzophenone,2-Amino-5-Chloro-2'-Fluoro- Methanone,(2-Amino-5-Chlorophenyl)(2-Fluorophenyl)- 2-Amino-2'-Fluoro-5-Chlorophenyl-PhenylMenthanine (2-Amino-5-chlorophenyl)(2-fluorophenyl)methanone

Molecular Formula: C13H9ClFNO

Molecular Weight: 249.67

MDL Number: MFCD00038381

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

2-Amino-5-chloro-2'-fluorobenzophenone is an important organic compound characterized by its benzophenone core structure substituted with an amino group at the 2-position, a chlorine atom at the 5-position, and a fluorine atom at the 2'-position of the second phenyl ring. It serves as a key synthetic intermediate in the pharmaceutical industry. Its primary and most significant application is in the synthesis of benzodiazepine-class drugs. Specifically, it is a crucial building block in the production of Flurazepam, a sedative-hypnotic medication used for the treatment of insomnia. The compound's structure contains the essential pharmacophoric elements required for constructing the 1,4-benzodiazepine ring system, making it a vital precursor in the manufacturing process of this class of central nervous system (CNS) agents. As a high-value pharmaceutical intermediate, its synthesis and purity are of critical importance. It is typically handled under controlled conditions in research and industrial settings dedicated to active pharmaceutical ingredient (API) production.

Physical Properties

Melting Point: 95-98 °C(lit.)

Boiling Point: 432.2 °C at 760 mmHg

Flash Point: 215.2 °C

Density: 1.342 g/cm3

Analytical Data

Appearance: yellow fine powder