1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, CAS No. 761446-44-0

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761446-44-0

Catalog No. EBD1614030

CAS 761446-44-0

Name 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

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Basic Information

Synonyms: 1-Methylpyrazole-4-boronicacidpinacolester 1-Methyl-4-1H-pyrazoleboronicacid,pinacolester 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-1H-pyrazole 1-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole 1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Molecular Formula: C10H17BN2O2

Molecular Weight: 208.07

MDL Number: MFCD03789259

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a heterocyclic boronic acid pinacol ester. Its structure features a pyrazole ring substituted with a methyl group at the 1-position and a pinacol boronate ester at the 4-position, making it a stable and versatile building block for cross-coupling reactions. This compound is primarily utilized as a key intermediate in medicinal chemistry for the synthesis of kinase inhibitors, antiviral agents, and other bioactive molecules. The boronate ester group enables Suzuki-Miyaura coupling to introduce the pyrazole moiety into complex drug scaffolds, particularly in the development of targeted cancer therapies and anti-inflammatory drugs. As a common synthetic building block, it is also widely employed in organic synthesis for constructing heterocyclic libraries and functional materials. Its high stability and reactivity under standard coupling conditions make it a preferred reagent in both academic research and industrial pharmaceutical development.

Physical Properties

Melting Point: 59-64 °C(lit.)

Boiling Point: 308.3 °C at 760 mmHg

Flash Point: 140.3 °C

Density: 1.05 g/cm3

Storage: Refrigerator (+4°C)

Analytical Data

Appearance: white to light yellow crystal powder