1,4-Dithia-7-azaspiro[4,4]nonane-8-carboxylic acid hydrobromide, CAS No. 75776-79-3

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75776-79-3

Catalog No. EBD42578

CAS 75776-79-3

Name 1,4-Dithia-7-azaspiro[4,4]nonane-8-carboxylic acid hydrobromide

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Basic Information

Synonyms: 1,4-Dithia-7-azaspiro(4,4)nonane-8-(S)-carboxylicacidhydrobromide (8S)-1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylicacidhydrobromide(1:1) 1,4-Dithia-7-azaspiro[4,4]nonane-8-carboxylicacidhydrobromide 1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylicacid,(8S)-,hydrobromide(1:1) (7S)-1,4-dithia-8-azaspiro[4.4]nonane-7-carboxylicacidhydrobromide

Molecular Formula: C7H12BrNO2S2

Molecular Weight: 286.21

MDL Number: MFCD07367991

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Nitrazepam, chemically known as 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one, is a benzodiazepine derivative. It is a white to yellowish crystalline powder, practically insoluble in water but soluble in organic solvents like chloroform and acetone. Its molecular formula is C₁₅H₁₁N₃O₃. Nitrazepam is primarily used as a sedative and hypnotic agent in the treatment of insomnia and certain types of epilepsy, particularly infantile spasms (West syndrome). It acts as a positive allosteric modulator of the GABA_A receptor in the central nervous system, enhancing the inhibitory effects of the neurotransmitter GABA, which results in sedative, hypnotic, anxiolytic, and anticonvulsant effects. Due to its potential for dependence, tolerance, and side effects such as drowsiness and ataxia, its use is now more restricted and typically recommended for short-term management. It is also a key intermediate in the synthesis of other benzodiazepine drugs.

Physical Properties

Boiling Point: 445.2 °C at 760 mmHg

Flash Point: 223 °C