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    75172-66-6

    Catalog No. EBD2224435

    CAS 75172-66-6

    Name 4-methoxymandelic acid

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    Basic Information

    Synonyms: (S)-(+)-p-methoxymandelicacid 4-methoxymandelicacid L-4-MethoxymandelicAcid

    Molecular Formula: C9H10O4

    Molecular Weight: 182.17

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    L-4-Methoxymandelic acid methyl ester is a chiral organic compound featuring a methyl ester group and a methoxy-substituted mandelic acid backbone. It is a white to off-white crystalline powder with a molecular formula of C10H12O4. This compound is characterized by its L-configuration, making it a valuable source of chirality in synthetic chemistry. Its primary and most significant application is as a key chiral intermediate in the pharmaceutical industry. It is extensively utilized in the synthesis of various active pharmaceutical ingredients (APIs), particularly those requiring a specific enantiomeric form for optimal biological activity. A notable example is its role in the production of Clopidogrel, a widely used antiplatelet drug for the prevention of heart attacks and strokes. The chiral center of this ester is crucial for constructing the active enantiomer of such drugs. Beyond its direct pharmaceutical use, this compound serves as a versatile chiral building block in organic synthesis. Its structure allows for further chemical transformations, making it useful for constructing more complex molecules in medicinal chemistry research and development.
    Physical Properties

    Boiling Point: 370.4 °C at 760 mmHg

    Flash Point: 152.6 °C

    Density: 1.309 g/cm3

    mg g kg ml l t