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    7418-65-7

    Catalog No. EBD5492

    CAS 7418-65-7

    Name 4-Aminonicotinic acid

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    Basic Information

    Synonyms: 4-Aminonicotinicacid 4-Aminopyridine-3-carboxylicacid 4-AminoNicotinicAcidMethyl 4-amino-3-pyridinecarboxylicacid

    Molecular Formula: C6H6N2O2

    Molecular Weight: 138.12

    MDL Number: MFCD00234183

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    4-Aminonicotinic acid is an organic compound featuring a pyridine ring substituted with an amino group at the 4-position and a carboxylic acid group at the 3-position. It is a white to off-white crystalline powder. This structure makes it a versatile heterocyclic building block. Its primary and most significant application is in the pharmaceutical industry as a key intermediate. It is widely used in the synthesis of various active pharmaceutical ingredients (APIs), particularly those belonging to the vitamin B3 (niacin) derivative family and other nicotinic acid-based drugs. It serves as a crucial precursor for compounds with potential biological activities. Beyond its role as a pharmaceutical intermediate, 4-aminonicotinic acid is also employed in organic synthesis and material science research due to its bifunctional nature (amine and carboxylic acid), which allows for further derivatization. It is considered a hazardous substance and requires careful handling, as it may cause skin and eye irritation.
    Physical Properties

    Melting Point: 307-312 °C

    Boiling Point: 395.834 °C at 760 mmHg

    Flash Point: 193.194 °C

    Density: 1.417 g/cm3

    Analytical Data

    Appearance: light yellow crystal

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