Nile Blue A oxazone, CAS No. 7385-67-3

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7385-67-3

Catalog No. EBD2204847

CAS 7385-67-3

Name Nile Blue A oxazone

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Basic Information

Synonyms: 9-(Diethylamino)benzo(a)phenoxazin-5(5H)-one 9-diethylamino-5H-benzo[α]phenoxazine-5-one NileBlueAoxazone 9-(diethylamino)benzo[a]phenoxazin-5(5H)-one Nilered 9-(Diethylamino)-5H-benzo(a)phenoxazin-5-one 5H-Benzo(a)phenoxazin-5-one,9-(diethylamino)-

Molecular Formula: C20H18N2O2

Molecular Weight: 318.37

MDL Number: MFCD00011639

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Fluorescent Probes and Labeling Reagents Materials Chemistry > Optoelectronic and Organic Semiconductor Materials > Dye Precursors

Product Description:

Nile Red, also known as Nile Blue A oxazone, is a lipophilic, solvatochromic benzophenoxazine dye. It is a red solid with a molecular formula of C20H18N2O2. The compound exhibits strong fluorescence, and its emission maximum is highly sensitive to the polarity of its local environment, shifting from deep red in nonpolar solvents to orange-yellow in more polar environments. Its primary and most significant application is in biological and biochemical research as a selective fluorescent stain for intracellular lipid droplets, particularly neutral lipids. This property makes it a vital tool for studying lipid metabolism, obesity, and related diseases. It is also used as a probe for membrane fluidity and in the detection of microplastics due to its affinity for hydrophobic polymers. Beyond life sciences, Nile Red serves as a model compound in photophysical studies and as a precursor or active component in the development of organic dyes and sensors for material science applications. The dye is generally considered to have low acute toxicity but should be handled with standard laboratory precautions, avoiding inhalation and contact with skin and eyes. Its stability and strong fluorescence quantum yield contribute to its widespread use in both fluorescence microscopy and spectroscopic analysis.

Physical Properties

Melting Point: 203-205 °C(lit.)

Boiling Point: 484.7°C at 760 mmHg

Flash Point: 246.9°C

Density: 1.23g/cm3

Solubility: Toxicity data (The meaning of any abbre"> Stability Stable. Incompatible with strong oxidizing agents. Toxicology Not hazardous according to Directive 67/548/EEC. Toxicity data (The meaning of any abbre

Analytical Data

Appearance: solid