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    73821-95-1

    Catalog No. EBD41283

    CAS 73821-95-1

    Name Boc-L-aspartic acid 4-cyclohexyl ester

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    Basic Information

    Synonyms: boc-L-asparticacid4-cyclohexylester Boc-Asp(OcHex)-OH BOC-Asp(OcHx)-OH 2-[(tert-butoxycarbonyl)amino]-4-(cyclohexyloxy)-4-oxobutanoicacid(non-preferredname) (2S)-2-[(tert-butoxycarbonyl)amino]-4-(cyclohexyloxy)-4-oxobutanoicacid(non-preferredname) (3S)-3-[(tert-butoxycarbonyl)amino]-4-(cyclohexyloxy)-4-oxobutanoicacid(non-preferredname)

    Molecular Formula: C15H25NO6

    Molecular Weight: 315.36

    MDL Number: MFCD00061996

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

    Product Description:
    Boc-Asp(OcHex)-OH, with CAS number 73821-95-1, is a protected derivative of aspartic acid. Its chemical structure features an L-aspartic acid core where the α-amino group is protected by a tert-butoxycarbonyl (Boc) group, and the side-chain β-carboxylic acid is protected as a cyclohexyl (OcHex) ester. This specific protection scheme renders the molecule highly valuable in peptide synthesis. This compound is primarily employed as a key building block in solid-phase and solution-phase peptide synthesis. The Boc protecting group on the amine is stable under basic conditions but can be cleanly removed under acidic conditions, while the cyclohexyl ester on the side chain provides orthogonal protection that is stable to the acidic conditions used for Boc deprotection but can be removed by hydrogenolysis or other methods. This allows for the selective incorporation of aspartic acid into peptide chains, enabling the synthesis of complex peptides and proteins for pharmaceutical research and development. Its application is crucial in the production of therapeutic peptides, where precise control over amino acid sequence and side-chain functionality is essential. The compound is a standard reagent in the toolkit of peptide chemists and is widely available from suppliers specializing in amino acid derivatives and peptide synthesis reagents.
    Physical Properties

    Melting Point: 93-95 °C

    Boiling Point: 487.2 °C at 760 mmHg

    Flash Point: 248.4 °C

    Density: 1.18 g/cm3

    Storage: −20°C

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