FMOC-SER, CAS No. 73724-45-5

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73724-45-5

Catalog No. EBD38726

CAS 73724-45-5

Name FMOC-SER

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Basic Information

Synonyms: Fmoc-L-Serine N-Fmoc-L-serinemonohydrate Fmoc-L-Ser-OH N-(9-Fluorenylmethoxycarbonyl)-L-serine Fmoc-Ser-OH N-Fmoc-L-serine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-hydroxypropanoate FMOC-SER

Molecular Formula: C18H17NO5

Molecular Weight: 327.33

MDL Number: MFCD00051928

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

N-Fmoc-L-serine is a protected derivative of the natural amino acid L-serine. Its structure features an L-serine backbone where the alpha-amino group is protected by a 9-fluorenylmethoxycarbonyl (Fmoc) group. This white to off-white crystalline powder is a fundamental and widely used building block in solid-phase peptide synthesis (SPPS). Its primary and most significant application is in the field of peptide chemistry. The Fmoc protecting group is base-labile and can be cleanly removed under mild conditions using piperidine, making N-Fmoc-L-serine a cornerstone reagent in Fmoc-based SPPS protocols. It is incorporated into peptide chains to introduce serine residues, which are crucial for phosphorylation sites, glycosylation sites, and contributing to the hydrophilicity and hydrogen-bonding network of the final peptide or protein. As a high-purity, commercially available amino acid derivative, it is a staple in research laboratories and pharmaceutical development for producing therapeutic peptides, peptide hormones, and biochemical probes. Proper handling requires standard laboratory precautions to avoid inhalation and contact.

Physical Properties

Melting Point: 104-106°C

Boiling Point: 599.3 °C at 760 mmHg

Flash Point: 316.2 °C

Density: 1.362 g/cm3

Refractivity: -12.5 ° (C=1, DMF)

Storage: 2-8°C