N-Boc-pyrroline, CAS No. 73286-70-1

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73286-70-1

Catalog No. EBD37659

CAS 73286-70-1

Name N-Boc-pyrroline

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Basic Information

Synonyms: N-Boc-2,5-dihydro-1H-pyrrole N-Boc-3-Pyrroline N-Boc-pyrroline N-T-BOC-2,5-DIHYDROPYRROLE 1-tert-Butoxycarbonylpyrroline tert-butyl2,3-dihydro-1H-pyrrole-1-carboxylate tert-butyl-2H-pyrrole-1(5H)-carboxylate Boc-3-pyrroline 1-Boc-3-pyrroline tert-butyl2,5-dihydro-1H-pyrrole-1-carboxylate, tert-Butyl2,5-dihydro-1H-pyrrole-1-carboxylate N-Boc-2,5-dihydropyrrole tert-Butyl2H-pyrrole-1(5H)-carboxylate 2,5-Dihydropyrrole-1-carboxylicacidtert-butylester 2,5-Dihydro-1H-pyrrole-1-carboxylicacid1,1-dimethylethylester

Molecular Formula: C9H15NO2

Molecular Weight: 169.22

MDL Number: MFCD01863512

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Boc-3-Pyrroline is a protected heterocyclic amine, specifically a Boc-protected derivative of 3-pyrroline. It serves as a versatile and crucial building block in organic synthesis, particularly for the construction of pyrrolidine and pyrrole ring systems, which are common structural motifs in pharmaceuticals and bioactive molecules. Its primary application is as a key intermediate in the synthesis of various drug candidates and active pharmaceutical ingredients (APIs). The Boc protecting group allows for selective manipulation of the nitrogen atom during multi-step synthetic sequences. This compound is frequently employed in the preparation of compounds with neurological, anti-infective, or anticancer activities, where the pyrrolidine scaffold is essential for biological activity. Due to its reactive double bond and protected amine functionality, N-Boc-3-pyrroline is a valuable precursor for ring-opening reactions, cycloadditions, and further functionalization. It is a standard reagent in medicinal chemistry research for exploring structure-activity relationships. Proper handling is required as it may be sensitive to strong acids and oxidizing agents.

Physical Properties

Boiling Point: 208 °C(lit.)

Flash Point: 81 °C

Density: 0.981 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.458(lit.)

Analytical Data

Appearance: White to yellow low melting solid or liquid