N-(2-Chloroethyl)pyrrolidine hydrochloride, CAS No. 7250-67-1

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

7250-67-1

Catalog No. EBD968979

CAS 7250-67-1

Name N-(2-Chloroethyl)pyrrolidine hydrochloride

Get Quote

Basic Information

Synonyms: N-(2-Chloroethyl)pyrrolidinehydrochloride N-(2-Chloroethyl)pyrrolidineHCl 2-(N-Pyrrolidino)ethylchloridehydrochloride N-ChloroethylpyrprolidineHCl 1-(2-Chloroethyl)pyrrolidinehydrochloride 2-Pyrrolidinoethylchloridehydrochloride 1-(2-chloroethyl)pyrrolidinium

Molecular Formula: C6H13Cl2N

Molecular Weight: 170.08

MDL Number: MFCD00012718

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-(2-Chloroethyl)pyrrolidine hydrochloride is an organic salt featuring a pyrrolidine ring linked to a chloroethylamine moiety. It is a white to off-white crystalline powder with a molecular formula of C6H13Cl2N. This compound is a versatile building block in organic synthesis, particularly valued for the reactivity of its chloroethyl group, which can undergo nucleophilic substitution reactions. Its primary and most significant application is in the pharmaceutical industry as a key intermediate. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs), including certain antipsychotic and neuroleptic drugs. The molecule serves as a crucial precursor for constructing pharmacologically important heterocyclic systems and introducing specific amine-containing side chains into target molecules. Due to its dual functionality (tertiary amine and alkyl chloride), it finds utility in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities. As a reactive intermediate, it requires careful handling under appropriate conditions, typically involving inert atmospheres and anhydrous solvents for further transformations.

Physical Properties

Melting Point: 167-170 °C(lit.)

Boiling Point: 170.5 °C at 760 mmHg

Flash Point: 56.9 °C

Solubility: Soluble

Analytical Data

Appearance: white to off-white crystals or crystalline powder