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    721960-43-6

    Catalog No. EBD670520

    CAS 721960-43-6

    Name 2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine

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    Basic Information

    Synonyms: 4-Amino-3-chlorophenylboronicacid,pinacolester 2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 4-amino-3-chlorophenylboronicacidpinacolester Benzenamine,2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

    Molecular Formula: C12H17BClNO2

    Molecular Weight: 253.54

    MDL Number: MFCD09998359

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    4-Amino-3-chlorophenylboronic acid pinacol ester is a protected boronic acid derivative. It features an amino group and a chlorine atom on the phenyl ring, with the boronic acid functionality masked as a pinacol ester. This protection enhances its stability, solubility in organic solvents, and handling characteristics compared to the free boronic acid. This compound serves as a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. The protected boronate ester is a key intermediate for constructing biaryl structures containing both amino and chloro substituents. Its primary application is in pharmaceutical research and development, where it is used to synthesize complex molecules, including potential drug candidates and active pharmaceutical ingredients (APIs). The presence of both an amino group (a handle for further functionalization) and a chloro group (which can participate in various coupling or substitution reactions) makes it a valuable and multifunctional synthon in medicinal chemistry.
    Physical Properties
    mg g kg ml l t