(R)-(-)-Tetrahydrofurfurylamine, CAS No. 7202-43-9

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7202-43-9

Catalog No. EBD2218991

CAS 7202-43-9

Name (R)-(-)-Tetrahydrofurfurylamine

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Basic Information

Synonyms: (R)-(-)-Tetrahydrofurfurylamine (R)-(-)-2-(Aminomethyl)tetrahydrofuran (R)-(tetrahydrofuran-2-yl)methanamine (R)-TETRAHYDROFURFURYLAMINE 1-[(2R)-tetrahydrofuran-2-yl]methanamine (R)-2-Tetrahydrofurfurylamine (r)-(-)-2-(aminomethyl)tetrahydrofurane

Molecular Formula: C5H11NO

Molecular Weight: 101.15

MDL Number: MFCD00192476

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-2-(Aminomethyl)tetrahydrofuran is a chiral amine compound featuring a tetrahydrofuran ring. It serves as a versatile chiral building block in organic synthesis, particularly valued for its rigid, oxygen-containing heterocyclic structure and a primary amine functional group. Its primary and most significant application is in the pharmaceutical industry as a key chiral intermediate. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs), including certain antiviral and central nervous system (CNS) drugs. The chiral center is crucial for imparting specific biological activity and is often incorporated into final drug molecules to achieve desired pharmacological profiles. Beyond its role as a pharmaceutical intermediate, this compound is also employed in academic and industrial research for constructing complex molecules, making it a relevant item in the category of organic synthesis building blocks. It typically requires handling under inert atmosphere due to the reactivity of the primary amine group.

Physical Properties

Boiling Point: 55 °C/18 mmHg(lit.)

Flash Point: 46 °C

Density: 0.98 g/mL at 25 °C(lit.)

Solubility: miscible

Refractivity: n20/D 1.455(lit.)

Storage: Flammables area

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 2943