FMOC-L-Proline, CAS No. 71989-31-6

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71989-31-6

Catalog No. EBD8458

CAS 71989-31-6

Name FMOC-L-Proline

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Basic Information

Synonyms: 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]proline 1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylicacid 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-proline (2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylate Fmoc-L-Proline Fmoc-L-Pro-OH 1,2-pyrrolidinedicarboxylicacid,1-(9H-fluoren-9-ylmethyl)ester N-(9-Fluorenylmethoxycarbonyl)-L-proline Fmoc-Pro-OH

Molecular Formula: C20H19NO4

Molecular Weight: 337.37

MDL Number: MFCD00037122

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

FMOC-L-Proline is a derivative of the amino acid L-proline, where the amino group is protected by the 9-fluorenylmethoxycarbonyl (Fmoc) group. It appears as a white to off-white crystalline powder and is a key building block in solid-phase peptide synthesis (SPPS). Its primary application is in the Fmoc-based synthesis of peptides, where it serves as a protected proline monomer. The Fmoc group is base-labile, allowing for selective deprotection under mild conditions, making it ideal for constructing complex peptides and proteins. It is widely used in pharmaceutical research for developing peptide-based drugs and in biochemical studies. Additionally, FMOC-L-Proline is a versatile synthetic intermediate in organic chemistry, often employed as a chiral building block for preparing proline-containing compounds or as a starting material for further functionalization. It is stable under standard storage conditions and is a standard reagent in peptide chemistry laboratories.

Physical Properties

Melting Point: 117-118 °C(lit.)

Boiling Point: 548.6 °C at 760 mmHg

Flash Point: 285.6 °C

Density: 1.328 g/cm3

Refractivity: -32.5 ° (C=1, DMF)

Storage: 2-8°C

Analytical Data

Appearance: white to light yellow crystal powder