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    7127-19-7

    Catalog No. EBD18715

    CAS 7127-19-7

    Name 2-Phenyl-4,5-dihydrooxazole

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    Basic Information

    Synonyms: 2-phenyl-2-oxazoline 4,5-Dihydro-2-phenyloxazole 2-Phenyl-4,5-dihydro-oxazole 2-phenyl-4,5-dihydro-1,3-oxazole 2-Phenyl-4,5-dihydrooxazole

    Molecular Formula: C9H9NO

    Molecular Weight: 147.17

    MDL Number: MFCD00466256

    Categories: Synthetic Chemistry > Catalysts and Ligands > Organocatalysts

    Product Description:
    4,5-Dihydro-2-phenyloxazole is a heterocyclic organic compound featuring a saturated oxazoline ring substituted with a phenyl group at the 2-position. It is a versatile building block and reagent in synthetic organic chemistry. This compound is primarily employed as a precursor or intermediate in the synthesis of more complex heterocyclic systems and functionalized molecules. A significant application is its use as a chiral auxiliary or ligand in asymmetric synthesis. Derivatives of 2-phenyloxazoline are well-known as effective ligands for transition metal-catalyzed reactions, including asymmetric hydrogenations and carbon-carbon bond-forming processes. It also serves as a key starting material for preparing various pharmaceuticals and agrochemicals. As a stable, crystalline solid, it is a convenient handle for introducing the oxazoline moiety, which can be further functionalized or hydrolyzed to yield β-amino alcohols or other valuable synthons.
    Physical Properties

    Melting Point: 12 °C(lit.)

    Boiling Point: 75 °C/0.3 mmHg(lit.)

    Flash Point: 113 °C

    Density: 1.118 g/mL at 25 °C(lit.)

    Refractivity: n20/D 1.567(lit.)

    mg g kg ml l t