6-Nitrobenzo[d][1,3]dioxole-5-carbaldehyde, CAS No. 712-97-0

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712-97-0

Catalog No. EBD37273

CAS 712-97-0

Name 6-Nitrobenzo[d][1,3]dioxole-5-carbaldehyde

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Basic Information

Synonyms: 6-Nitrobenzo[d][1,3]dioxole-5-carbaldehyde 6-Nitropiperonal (3,4-Methylenedioxy-6-nitrobenzald 4,5-Methylenedioxy-2-nitrobenzaldehyde 6-Nitro-1,3-benzodioxole-5-carboxaldehyde 6-nitro-1,3-benzodioxole-5-carbaldehyde 4,5-(Methylenedioxy)-2-nitrobenzaldehyde

Molecular Formula: C8H5NO5

Molecular Weight: 195.13

MDL Number: MFCD00005829

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

6-Nitrobenzo[d][1,3]dioxole-5-carbaldehyde is a heterocyclic aromatic aldehyde characterized by a 1,3-benzodioxole (methylenedioxyphenyl) core substituted with a nitro group and a formyl group. It serves as a crucial synthetic intermediate in medicinal chemistry. Its primary application is in the synthesis of various biologically active compounds. Most notably, it is a key building block for the preparation of piperonal derivatives, which are important precursors for pharmaceuticals, agrochemicals, and fine chemicals. The aldehyde group allows for further functionalization through reactions like condensation, reduction, or nucleophilic addition, making it a versatile starting point for constructing complex molecular architectures. While its main use is as a pharmaceutical intermediate, its well-defined structure also makes it a valuable specialty organic synthesis block for research and development in heterocyclic chemistry.

Physical Properties

Melting Point: 93-94 °C(lit.)

Boiling Point: 365.9 °C at 760 mmHg

Flash Point: 195 °C

Density: 1.572 g/cm3

Analytical Data

Appearance: yellow powder.