Trans-(1R,2R)-N,N'-Dimethyl-cyclohexane-1,2-diamine dihydrochloride is a chiral diamine compound, specifically the dihydrochloride salt of the trans-(1R,2R) enantiomer. It is a white to off-white crystalline powder, commonly used as a high-purity chiral ligand or catalyst precursor in asymmetric synthesis. Its primary application is in the field of enantioselective catalysis. The compound serves as a key precursor for the synthesis of chiral salen-type ligands and other transition metal complexes, particularly with copper, ruthenium, and iridium. These complexes are widely employed in asymmetric transformations such as cyclopropanation, aziridination, and various C-H functionalization reactions. The rigid, chiral cyclohexane backbone and the dimethylamino groups are crucial for inducing high enantioselectivity in these catalytic processes. As a building block, it is also utilized in the preparation of chiral auxiliaries and organocatalysts. The dihydrochloride salt form offers improved stability and handling compared to the free base. It is a specialty chemical of significant importance in academic research and pharmaceutical process development for constructing chiral centers.