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    701-45-1

    Catalog No. EBD264245

    CAS 701-45-1

    Name Benzene, 2-bromo-1-fluoro-4-nitro-

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    Basic Information

    Synonyms: 2-bromo-1-fluoro-4-nitrobenzene 3-Bromo-4-fluoronitrobenzene 3-Bromo-4-Fluoro-1-Nitrobenzene Benzene,2-bromo-1-fluoro-4-nitro-

    Molecular Formula: C6H3BrFNO2

    Molecular Weight: 220.0

    MDL Number: MFCD00055433

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    3-Bromo-4-fluoronitrobenzene is an organic compound characterized by a benzene ring substituted with bromine, fluorine, and nitro groups. It serves as a versatile and important multi-halogenated aromatic building block in synthetic organic chemistry. Its primary application is as a key intermediate in the synthesis of more complex molecules, particularly in pharmaceutical research. The presence of three distinct reactive sites (bromo, fluoro, and nitro groups) allows for selective functional group transformations, such as nucleophilic aromatic substitution (especially of the fluorine atom) or metal-catalyzed cross-coupling reactions (using the bromine atom). This makes it valuable for constructing substituted aniline derivatives, which are common scaffolds in active pharmaceutical ingredients (APIs) and agrochemicals. As a halogenated nitroarene, it requires careful handling due to potential toxicity and irritant properties. It is typically used in laboratory-scale synthesis and process development within the fine chemical and pharmaceutical industries.
    Physical Properties

    Melting Point: 55°C

    Boiling Point: 250.6 °C at 760 mmHg

    Flash Point: 105.4 °C

    Density: 1.808 g/cm3

    Analytical Data

    Appearance: colorless to light yellow liquid

    mg g kg ml l t