2-Fluoroadenine, CAS No. 700-49-2

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700-49-2

Catalog No. EBD51582

CAS 700-49-2

Name 2-Fluoroadenine

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Basic Information

Synonyms: 2-Fluoroadenine 2-Fluoro-7(9)H-purin-6-ylamine 2-Fluoro-6-aminopurine

Molecular Formula: C5H4FN5

Molecular Weight: 153.12

MDL Number: MFCD01632749

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

2-Fluoroadenine is a purine derivative characterized by a fluorine atom substituted at the 2-position of the adenine ring system. It serves as a crucial synthetic intermediate and a key building block in medicinal chemistry. Its primary application is in the synthesis of fluorinated nucleoside analogues, which are important as potential antiviral and anticancer agents. For instance, it is a direct precursor to 2-fluoroadenosine and its derivatives. These compounds act as antimetabolites, interfering with DNA/RNA synthesis and exhibiting significant biological activity. Research has explored its role in developing treatments for conditions like leukemia and viral infections. As a fluorinated heterocyclic compound, it represents a valuable scaffold for structure-activity relationship (SAR) studies in drug discovery, aiming to enhance the potency, selectivity, and metabolic stability of nucleoside-based therapeutics.

Physical Properties

Melting Point: >350 °C(lit.)

Boiling Point: 676.9 °C at 760 mmHg

Flash Point: 363.2 °C

Density: 1.739 g/cm3

Analytical Data

Appearance: white to light yellow crystal powder