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    696-74-2

    Catalog No. EBD579338

    CAS 696-74-2

    Name (+/-)-cis-cyclopropane dicarboxylic acid

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    Basic Information

    Synonyms: (+/-)-cis-cyclopropanedicarboxylicacid cis-cyclopropane-1,2-dicarboxylicacid (Z)-1,2-cyclopropanedicarboxylicacid cis-1,2-cyclopropanedicarboxylicacid cis-1,2-cyclopropyldicarboxylicacid cis-Cyclopropan-1,2-dicarbonsaeure (1R,2S)-cyclopropane-1,2-dicarboxylicacid 1,2-cyclopropanedicarboxylicacid,(1R,2S)-

    Molecular Formula: C5H6O4

    Molecular Weight: 130.1

    Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    (±)-cis-Cyclopropane-1,2-dicarboxylic acid is a chiral, cyclic dicarboxylic acid featuring a strained three-membered cyclopropane ring. This structural motif imparts unique chemical and conformational properties, making it a valuable building block in organic synthesis. The compound exists as a racemic mixture of the cis-isomer. Its primary application is as a versatile synthetic intermediate, particularly in medicinal chemistry. The rigid cyclopropane scaffold is a privileged structure in drug design, often used to mimic peptide bonds or to lock bioactive conformations, thereby improving metabolic stability and binding affinity. This dicarboxylic acid serves as a key precursor for the synthesis of various pharmacologically active compounds, including enzyme inhibitors and ligands for biological targets. While not a final Active Pharmaceutical Ingredient (API) itself, its role is firmly established in the construction of complex molecular architectures for pharmaceutical research and development. It is commercially available from chemical suppliers specializing in fine chemicals and building blocks for synthesis.
    Physical Properties

    Boiling Point: 305.8°C at 760 mmHg

    Flash Point: 153°C

    Density: 1.673g/cm3

    mg g kg ml l t