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    69555-14-2

    Catalog No. EBD677534

    CAS 69555-14-2

    Name Ethyl N-(diphenylmethylene)glycinate

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    Basic Information

    Synonyms: diphenylmethyleneglycineethylester diphenylmethyleneglycineester ethyl2-(diphenylmethyleneamino)acetate diphenylmethylene-glycineethylesert dpm-gly-oet ethylN-(diphenylmethylidene)glycinate N-(diphenylmethylene)glycineethylester

    Molecular Formula: C17H17NO2

    Molecular Weight: 267.32

    MDL Number: MFCD00010590

    Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

    Product Description:
    Diphenylmethylene glycine ethyl ester is a versatile organic compound characterized by a diphenylmethylene (benzhydrylidene) group protecting the amino functionality of a glycine ethyl ester backbone. This structure renders it a valuable, non-nucleophilic base and a protected glycine synthon in organic synthesis. Its primary application is as a reagent in peptide synthesis and the preparation of α-amino acids. The benzhydrylidene group acts as an effective protecting group for the amine, which can be selectively removed under mild acidic conditions. This makes it particularly useful for the synthesis of complex peptides and for introducing glycine derivatives into target molecules without racemization issues common with other methods. Furthermore, it serves as a precursor for various heterocyclic compounds and is employed in pharmaceutical research for constructing key intermediates. Its utility as a hindered organic base in certain coupling reactions also contributes to its role as a fundamental building block in medicinal and synthetic chemistry laboratories.
    Physical Properties

    Melting Point: 51-53 °C(lit.)

    Boiling Point: 357.9 °C at 760 mmHg

    Flash Point: 110 °C

    Density: 1.04 g/cm3

    Storage: 2-8°C

    Analytical Data

    Appearance: white to light yellow crystalline powder

    mg g kg ml l t