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    68527-67-3

    Catalog No. EBD109966

    CAS 68527-67-3

    Name 6-Bromo-8-nitroquinoline

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    Basic Information

    Molecular Formula: C9H5BrN2O2

    Molecular Weight: 253.05

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    6-Bromo-8-nitroquinoline is a halogenated and nitrated heterocyclic compound. It serves as a versatile and valuable building block in organic synthesis, particularly in medicinal chemistry. The presence of both bromine and nitro groups at specific positions on the quinoline scaffold makes it a reactive intermediate for further functionalization through cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and reduction reactions. Its primary application is in the research and development of pharmaceutical agents. This compound is frequently utilized as a key synthetic precursor for the construction of more complex quinoline derivatives with potential biological activities. These target molecules are often investigated for their therapeutic properties, including antimicrobial, anticancer, and anti-inflammatory effects. As a bifunctional intermediate, it allows for sequential and diverse chemical modifications, enabling the rapid exploration of structure-activity relationships (SAR) in drug discovery programs. Proper handling is required due to the typical hazards associated with nitroaromatic compounds.
    Physical Properties

    Boiling Point: 365.8 °C at 760 mmHg

    Flash Point: 175 °C

    Density: 1.747 g/cm3

    mg g kg ml l t