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    67805-67-8

    Catalog No. EBD37367

    CAS 67805-67-8

    Name 8-Bromoquinolin-2(1H)-one

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    Basic Information

    Synonyms: 8-bromoquinolin-2(1H)-one 8-Bromo-2(1H)-quinolinone

    Molecular Formula: C9H6BrNO

    Molecular Weight: 224.05

    MDL Number: MFCD08741409

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    8-Bromoquinolin-2(1H)-one is a heterocyclic organic compound featuring a quinolin-2-one core substituted with a bromine atom at the 8-position. This structure serves as a versatile and valuable synthetic building block, particularly in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of various pharmacologically active compounds. The bromine atom provides a reactive handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), enabling the construction of complex molecules. It is notably used in the research and development of kinase inhibitors and other small molecule therapeutics targeting diverse biological pathways. As a halogenated heterocycle, it is a fundamental reagent in organic synthesis for constructing quinoline-based scaffolds. Its dual role as a specialized pharmaceutical intermediate and a general-purpose synthetic building block underscores its importance in both applied and exploratory chemical research.
    Physical Properties

    Boiling Point: 390.243 °C at 760 mmHg

    Flash Point: 189.813 °C

    Density: 1.62g/cm3

    mg g kg ml l t