[2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] butanoate, CAS No. 6677-99-2

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6677-99-2

Catalog No. EBD79765

CAS 6677-99-2

Name [2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] butanoate

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Basic Information

Synonyms: 11β,17,21-trihydroxypregn-4-ene-3,20-dione21-butyrate Hydrocortisone21-butyrate Ceneo HB(sub21) Hydrocortisone-21-butyrate Isdinium SteroTo 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione21-butyrate Cortisol,21-butyrate Pregn-4-en-3,20-dione,11,17-dihydroxy-21-(1-oxobutoxy)-,(11-beta)-(9CI) (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-ylbutanoate [2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl]butanoate [2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]butanoate

Molecular Formula: C25H36O6

Molecular Weight: 432.55

Categories: Medicinal Chemistry > APIs and Their Salts > Dermatological Drugs Medicinal Chemistry > APIs and Their Salts > Immuno-modulators and Anti-inflammatory Drugs

Product Description:

Hydrocortisone 21-butyrate is a synthetic corticosteroid ester, specifically the 21-butyrate ester of hydrocortisone. It is a white to off-white crystalline powder. This modification enhances the lipophilicity and skin penetration of the parent hydrocortisone molecule. Its primary application is as a topical corticosteroid in dermatology. It acts as an anti-inflammatory, immunosuppressive, and antipruritic agent by binding to glucocorticoid receptors, thereby inhibiting the production of pro-inflammatory mediators. It is used in the treatment of various inflammatory skin conditions such as eczema, dermatitis, and psoriasis. Compared to hydrocortisone, the butyrate ester often exhibits increased potency and duration of action in topical formulations. As a defined chemical entity, it is considered an active pharmaceutical ingredient (API) or a derivative thereof. It is typically formulated into creams, ointments, or lotions for external use. Proper handling requires adherence to safety data sheet guidelines, as with all potent pharmaceuticals.

Physical Properties

Boiling Point: 594.8°C at 760 mmHg

Flash Point: 197.7°C

Density: 1.23g/cm3