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    66514-99-6

    Catalog No. EBD3106286

    CAS 66514-99-6

    Name (S)-4-amino-3-(4-chlorophenyl)butanoic acid

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    Basic Information

    Synonyms: (betaS)-beta-(Aminomethyl)-4-chlorobenzenepropanoicacid (S)-4-amino-3-(4-chlorophenyl)butanoicacid L-Baclofen (+)-Baclofen (L)-Baclofen (S)-Baclofen L-(+)-Baclofen S(+)-Baclofen UNII-3OHN4989XM

    Molecular Formula: C10H12ClNO2

    Molecular Weight: 213.66

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    (S)-4-Amino-3-(4-chlorophenyl)butanoic acid is a chiral, non-proteinogenic amino acid derivative. It features a 4-chlorophenyl group and a butanoic acid backbone with an amino group at the gamma position. This specific (S)-enantiomer is a key synthetic intermediate in the production of important pharmaceutical compounds. Its primary and most significant application is in the synthesis of Baclofen, a gamma-aminobutyric acid (GABA) derivative used as a muscle relaxant and antispastic agent for treating conditions like multiple sclerosis and spinal cord injuries. The (S)-enantiomer is the pharmacologically active form of Baclofen. This compound serves as a crucial chiral building block, enabling the efficient and stereoselective construction of the GABAergic pharmacophore essential for the drug's biological activity. As a high-value pharmaceutical intermediate, its synthesis and supply are critical for the manufacturing of the active pharmaceutical ingredient (API) Baclofen. Its chirality is paramount, as the biological activity resides predominantly in this specific stereoisomer.
    Physical Properties

    Boiling Point: 364.3°Cat760mmHg

    Flash Point: 174.1°C

    Density: 1.285g/cm3

    mg g kg ml l t