2-Chloro-3-Hydroxypyridine, CAS No. 6636-78-8

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6636-78-8

Catalog No. EBD541070

CAS 6636-78-8

Name 2-Chloro-3-Hydroxypyridine

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Basic Information

Synonyms: 2-Chlorpyridin-3-ol 2-cloropiridin-3-ol 2-chloropyridine-3-ol 2-Chloro-3-hydroxypyridine 2-Chloro-Pyridine-3-ol 2-chloro-3-hdyroxypyridine 3-Pyridinol,2-chloro- 2-Chloro-3-pyridinol 2-Chloro-pyridin-3-ol 2-chloro-3-pyridino 2-chloropyridin-3-ol 2-chloro-3-hydroxylpyridine 2-dichloro-3-hydroxypyridine

Molecular Formula: C5H4ClNO

Molecular Weight: 129.54

MDL Number: MFCD00006235

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2-Chloro-3-hydroxypyridine is a heterocyclic building block featuring a pyridine ring substituted with a chlorine atom at the 2-position and a hydroxyl group at the 3-position. Its molecular formula is C5H4ClNO, with a molecular weight of 129.54 g/mol. This compound is a white to light yellow crystalline solid, commonly used as a key intermediate in organic synthesis. Its primary application lies in the pharmaceutical industry, where it serves as a versatile intermediate for the synthesis of various bioactive molecules, including kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs. The chlorine and hydroxyl groups enable further functionalization, such as cross-coupling reactions or ether formation, making it valuable for constructing complex heterocyclic scaffolds. Additionally, 2-chloro-3-hydroxypyridine is employed as a general synthetic building block in medicinal chemistry and agrochemical research. It is also used in the preparation of ligands for metal complexes and as a precursor for pyridine-based materials. Due to its reactivity, it should be handled with standard laboratory safety precautions, avoiding contact with strong oxidizers.

Physical Properties

Melting Point: 170-172 °C(lit.)

Boiling Point: 316.2 °C at 760 mmHg

Flash Point: 145 °C

Density: 1.392 g/cm3

Analytical Data

Appearance: light beige powder