(R)-3-Amino-1,2-propanediol, CAS No. 66211-46-9

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66211-46-9

Catalog No. EBD33346

CAS 66211-46-9

Name (R)-3-Amino-1,2-propanediol

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Basic Information

Synonyms: 1,2-Propanediol,3-amino-,(2R)- (R)-(+)-3-Amino-1,2-propanediol (2R)-3-Aminopropane-1,2-diol (R)-3-Amino-1,2-propanediol (+)-3-amino-1,2-propanediol (r)-3-aminopropane-1,2-diol 3-amino-(2r)-1,2-propanediol (2r)-2,3-dihydroxypropylamine 1,2-propanediol,3-amino-,(r)-

Molecular Formula: C3H9NO2

Molecular Weight: 9111.0

MDL Number: MFCD00798261

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

(R)-3-Amino-1,2-propanediol is a chiral amino alcohol with a molecular formula of C3H9NO2. It serves as a crucial chiral building block in organic synthesis, particularly valued for its (R)-configuration. Its structure features both amino and diol functional groups, making it a versatile intermediate for constructing more complex molecules. The primary application of (R)-3-amino-1,2-propanediol is in the pharmaceutical industry as a key intermediate for the synthesis of various active pharmaceutical ingredients (APIs). It is notably used in the production of beta-blockers, such as (S)-dihydroalprenolol, and other cardiovascular drugs. Furthermore, it is a precursor for the synthesis of phospholipids and serves as a starting material for chiral ligands and catalysts used in asymmetric synthesis. This compound is also relevant in life science research, where it can be used to modify peptides or as a component in the synthesis of bioactive molecules. It is typically handled as a hygroscopic solid and requires storage under inert conditions to maintain stability.

Physical Properties

Melting Point: 54-56°C

Boiling Point: 117-119 °C0.4 mm Hg(lit.)

Flash Point: 113 °C

Density: 1.175 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.483(lit.)

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3259PSN1

Analytical Data

Appearance: white to light yellow crystal powder