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    661463-17-8

    Catalog No. EBD1000178

    CAS 661463-17-8

    Name 4-bromo-6-fluoro-quinoline

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    Basic Information

    Synonyms: 4-bromo-6-fluoro-quinoline 4-bromo-6-fluoroquinoline

    Molecular Formula: C9H5BrFN

    Molecular Weight: 226.05

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    4-Bromo-6-fluoroquinoline is a halogenated quinoline derivative, specifically a bromo-fluoro substituted heterocyclic compound. It serves as a versatile and important building block in medicinal chemistry and organic synthesis. Its primary application is as a key intermediate in the synthesis of various biologically active molecules, particularly in pharmaceutical research. The presence of both bromine and fluorine atoms at specific positions on the quinoline scaffold makes it a valuable precursor for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) or nucleophilic aromatic substitution. It is notably used in the development of kinase inhibitors and other therapeutic agents targeting various diseases. As a bifunctionalized heterocyclic scaffold, it is a common starting material for constructing more complex molecular architectures. Its utility stems from the reactivity of the halogen atoms, which allow for precise structural modifications to optimize drug candidate properties such as potency, selectivity, and metabolic stability.
    Physical Properties

    Boiling Point: 299.7°C at 760 mmHg

    Flash Point: 135.1°C

    Density: 1.647g/cm3

    mg g kg ml l t