Pergolide mesylate salt, CAS No. 66104-23-2

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

66104-23-2

Catalog No. EBD27014

CAS 66104-23-2

Name Pergolide mesylate salt

Get Quote

Basic Information

Synonyms: Pergolidemesylate 8-beta-((Methylthio)methyl)-6-propylergolinemethanesulfonate 8-beta-((Methylthio)methyl)-6-propylergolinemonomethanesulfonate 8beta-((Methylthio)methyl)-6-propylergolinemonomethanesulfonate Ergoline,8-((methylthio)methyl)-6-propyl-,monomethanesulfonate,(8beta)- LY127809 MPE Permax UNII-55B9HQY616 Ergoline,8-beta-((methylthio)methyl)-6-propyl-,methanesulfonate(1:1) Pergolidemesylatesalt 8beta-[(Methylthio)methyl]-6-propylergolinemethanesulfonatesalt Pergolide Mesylate

Molecular Formula: C20H30N2O3S2

Molecular Weight: 410.59

MDL Number: MFCD00153859

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Pergolide mesylate is the mesylate salt of pergolide, a synthetic ergoline derivative. It is a dopamine receptor agonist, primarily acting on D1 and D2 receptors, with a chemical structure based on a modified ergoline ring system. Its primary and well-established application is as an active pharmaceutical ingredient (API) for the treatment of Parkinson's disease and certain hyperprolactinemia conditions. It was historically used as an adjunct therapy to levodopa to manage motor fluctuations. Due to its role as a finished drug substance, it is categorized under neurological drugs. The compound also serves as a key intermediate or reference standard in pharmaceutical research and development related to dopaminergic agents. It is important to note that pergolide mesylate has been associated with serious side effects, including cardiac valvulopathy, leading to its withdrawal or restricted use in many markets. Current handling and research involving this compound require strict adherence to safety protocols and regulatory guidelines.

Physical Properties

Color: white

Melting Point: 252-254°C

Boiling Point: 491.3 °C at 760 mmHg

Flash Point: 250.9 °C

Storage: −20°C

Safety Information

Packing Level: II

Hazard Category: 6.1

Transport Codes: 1544PSN1

Analytical Data

Appearance: White to off-white solid