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    65645-32-1

    Catalog No. EBD24866

    CAS 65645-32-1

    Name (R)-4-(1-Aminoethyl)aniline dihydrochloride

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    Basic Information

    Synonyms: Benzenemethanamine,4-amino-a-methyl-,(aR)- Benzenemethanamine,4-amino-a-methyl-,(R)- R-(+)-a-Methyl-p-aminobenzylamine (R)-4-(1-Aminoethyl)anilinedihydrochloride

    Molecular Formula: C8H14Cl2N2

    Molecular Weight: 209.12

    MDL Number: MFCD12756018

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-4-(1-Aminoethyl)aniline dihydrochloride is a chiral aromatic amine derivative. It serves as a key chiral building block in pharmaceutical synthesis. The compound features a primary amine group on the ethyl side chain and a primary aniline group on the aromatic ring, both protected as hydrochloride salts for stability. Its primary application is as a crucial intermediate in the synthesis of chiral active pharmaceutical ingredients (APIs). The (R)-configured chiral center makes it particularly valuable for constructing molecules with specific stereochemical requirements, often found in drugs targeting the central nervous system or as enzyme inhibitors. It is frequently utilized in the preparation of compounds with dopaminergic or adrenergic activity. This high-purity chiral intermediate is essential for research and development in medicinal chemistry, enabling the efficient production of enantiomerically pure drug candidates. Handling requires standard precautions for amine hydrochlorides and should be conducted in a well-ventilated environment.
    Physical Properties
    mg g kg ml l t