L-Phenylglycinamide, CAS No. 6485-52-5

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6485-52-5

Catalog No. EBD20878

CAS 6485-52-5

Name L-Phenylglycinamide

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Basic Information

Synonyms: L-PHENYLGLYCINEAMIDE (2S)-2-amino-2-phenylethanamide L-α-Phenylglycinamide (S)-Phenylglycinamide H-Phg-Nh2Hcl L-Phenylglycinamide

Molecular Formula: C8H11ClN2O

Molecular Weight: 186.64

MDL Number: MFCD03791027

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

L-Phenylglycinamide is a chiral amino acid derivative, specifically the amide of L-phenylglycine. It serves as a crucial chiral building block and intermediate in the pharmaceutical industry. Its primary and most significant application is in the synthesis of β-lactam antibiotics, most notably serving as a key side-chain precursor for semisynthetic penicillins (e.g., ampicillin) and cephalosporins. The compound's value lies in its stereochemistry; the L-configuration is essential for the biological activity of the final antibiotic products. Its synthesis and supply are therefore critical for the production of these widely used anti-infective drugs. As a high-purity chiral intermediate, it is a staple in the fine chemical and active pharmaceutical ingredient (API) manufacturing sectors.

Physical Properties

Boiling Point: 322.8 °C at 760 mmHg

Flash Point: 149 °C

Density: 1.178 g/cm3