(S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride, CAS No. 645-35-2

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645-35-2

Catalog No. EBD35374

CAS 645-35-2

Name (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride

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Basic Information

Synonyms: L-Histidinehydrochloridesolution histidinehydrochloride L-Histidinehydrochloride L-histidinemonohydrochloride L-histidinehydrochloride(1:1) 1-carboxy-2-(1H-imidazol-5-yl)ethanaminiumchloride CCRIS7814 2-{[4-(1-methylethyl)phenyl]methylidene}-3-oxo-2,3-dihydro-1-benzofuran-6-ylcyclohexanecarboxylate (S)-2-Amino-3-(1H-imidazol-4-yl)propanoicacidhydrochloride

Molecular Formula: C6H10ClN3O2

Molecular Weight: 191.62

MDL Number: MFCD00064556

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Medicinal Chemistry > Pharmaceutical Excipients > Isotonic Agents, pH Adjusters, and Buffers

Product Description:

L-Histidine hydrochloride is the hydrochloride salt of the essential amino acid L-histidine. It is a white to off-white crystalline powder that is soluble in water. As a basic amino acid, it possesses an imidazole side chain, which gives it unique buffering capacity and chemical reactivity. Its primary applications are in the pharmaceutical and biotechnology industries. In biopharmaceutical formulations, particularly for monoclonal antibodies and other protein therapeutics, L-histidine and its hydrochloride salt are widely used as buffering agents to maintain solution pH and stability. It also serves as a critical raw material in cell culture media for the production of biologics. Furthermore, L-histidine hydrochloride is utilized in the synthesis of peptides and as a nutritional supplement. This compound is generally recognized as safe (GRAS) for certain uses and is listed in various pharmacopoeias. Proper handling should involve standard laboratory precautions to avoid inhalation or contact with eyes and skin.

Physical Properties

Boiling Point: 458.9 °C at 760 mmHg

Flash Point: 231.3 °C

Storage: 2-8°C

Safety Information

Packing Level: III

Hazard Category: 8

Transport Codes: 1789