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    64248-64-2

    Catalog No. EBD2203037

    CAS 64248-64-2

    Name Benzonitrile, 2,5-difluoro-

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    Basic Information

    Synonyms: Benzonitrile,2,5-difluoro- 2,5-difluorobenzonitrile Benzonitrile,2,5-difluoro-(9CI) 2,5-Difluorobenzonitrile,98% 2,5-Difluorobenzonitrile98% 1-isothiocyanato-4-(trifluoromethoxy)benzene

    Molecular Formula: C7H3F2N

    Molecular Weight: 139.1

    MDL Number: MFCD00001777

    Categories: Synthetic Chemistry > Organic Building Blocks > Cyano Compounds Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    2,5-Difluorobenzonitrile is an organic compound featuring a benzonitrile core substituted with two fluorine atoms at the 2- and 5- positions. It is a colorless to pale yellow liquid or low-melting solid with a molecular formula of C7H3F2N. This compound is a versatile and important building block in synthetic organic chemistry. Its primary utility lies in its dual functional groups: the electron-withdrawing cyano group and the fluorine atoms. The cyano group can be readily transformed into other functionalities such as carboxylic acids, amides, or tetrazoles, while the fluorine atoms, particularly the one ortho to the cyano group, can participate in nucleophilic aromatic substitution reactions. This makes it a key precursor in the synthesis of various heterocycles, agrochemicals, and pharmaceutical intermediates. For instance, it serves as a starting material for the production of certain herbicides and fungicides, as well as for the construction of complex molecules in medicinal chemistry research. As a bifunctional aromatic synthon, 2,5-difluorobenzonitrile is valued for its role in introducing both fluorine atoms and a versatile nitrile handle into target molecules, enabling the development of compounds with modified physicochemical and biological properties.
    Physical Properties

    Melting Point: 33-35 °C(lit.)

    Boiling Point: 188 °C

    Flash Point: 172 °F

    Density: 1.26 g/cm3

    Analytical Data

    Appearance: white to light yellow crystal powder

    mg g kg ml l t