N-(tert-butoxycarbonyl)-L-norleucine, CAS No. 6404-28-0

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6404-28-0

Catalog No. EBD578304

CAS 6404-28-0

Name N-(tert-butoxycarbonyl)-L-norleucine

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Basic Information

Synonyms: N-(tert-butoxycarbonyl)-L-norleucine N-tert-butyloxycarbonyl-L-norleucine boc-L-norleucine Boc-L-Nle-OH Boc-Nle N±-Boc-L-aminocaproicacid N-(tert-butyloxycarbonyl)-L-norleucine (2S)-2-[(tert-butoxycarbonyl)amino]hexanoate Boc-Nle-OH N-Boc-L-norleucine N-(tert-butoxycarbonyl)norleucine Boc-norleucine L-norleucine,N-[(1,1-dimethylethoxy)carbonyl]- n-tert-butoxycarbonyl-l-norleucine norleucine,n-carboxy-,n-tert-butylester(7ci) norleucine,n-carboxy-,n-tert-butylester,l-(8ci)

Molecular Formula: C11H21NO4

Molecular Weight: 231.29

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

N-Boc-L-norleucine is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) protected form of L-norleucine. It is a white to off-white crystalline powder with a molecular formula of C₁₁H₂₁NO₄. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS) and solution-phase peptide chemistry. Its primary application is in the pharmaceutical industry as a key intermediate for the synthesis of various peptides and peptidomimetics. The Boc group provides orthogonal protection for the alpha-amino group, allowing for selective deprotection under acidic conditions without affecting other protecting groups commonly used in peptide assembly. This makes it an essential reagent for constructing complex peptide sequences, including those with therapeutic potential. N-Boc-L-norleucine is a fundamental and versatile synthon in organic and medicinal chemistry. It is widely used in research laboratories for developing novel bioactive compounds, drug candidates, and as a standard reagent for studying peptide structure-activity relationships. Proper handling is required as it may cause skin and eye irritation.

Physical Properties

Boiling Point: 362.1 °C at 760 mmHg

Flash Point: 172.8 °C

Density: 1.063 g/cm3

Storage: -15°C