Paroxetine maleate, CAS No. 64006-44-6

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64006-44-6

Catalog No. EBD54457

CAS 64006-44-6

Name Paroxetine maleate

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Basic Information

Synonyms: (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidinium (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidinemaleate Paroxetinemaleate

Molecular Formula: C23H24FNO7

Molecular Weight: 445.44

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Paroxetine maleate is the maleate salt form of paroxetine, a selective serotonin reuptake inhibitor (SSRI). It is a white to off-white crystalline powder. The compound is chemically known as (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate. Paroxetine maleate is an active pharmaceutical ingredient (API) used in the formulation of antidepressant and anti-anxiety medications. It functions by potently and selectively inhibiting the neuronal reuptake of serotonin, thereby increasing the concentration of serotonin in the synaptic cleft. This mechanism is central to its therapeutic effects in treating major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, and post-traumatic stress disorder. As a key API, paroxetine maleate is subject to strict pharmacopoeial standards. Its related substances and degradation products are critical for quality control. Therefore, paroxetine maleate and its impurities are also used as reference standards in analytical testing to ensure the purity, safety, and efficacy of the final drug product.

Physical Properties

Color: white to off-white

Melting Point: 136-138°C

Boiling Point: 451.7 °C at 760 mmHg

Flash Point: 227 °C

Density: 1.213 g/cm3

Solubility: DMSO: ~12 mg/mL in water

Storage: 2-8°C

Analytical Data

Appearance: white solid