Ammonium (S)-5-(4-amino-4-carboxybutanamido)-2-nitrobenzoate, CAS No. 63699-78-5

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63699-78-5

Catalog No. EBD572098

CAS 63699-78-5

Name Ammonium (S)-5-(4-amino-4-carboxybutanamido)-2-nitrobenzoate

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Basic Information

Synonyms: Glupa-carboxylate monoammonium salt Ammonium(S)-5-(4-amino-4-carboxybutanamido)-2-nitrobenzoate glutamicacid5-(3-carboxy-4-nitro-anilide)ammoniumS L-glutamicacidgamma-(3-carboxy-4-nitroanilide)ammoniumsalt

Molecular Formula: C12H16N4O7

Molecular Weight: 328.28

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics Medicinal Chemistry > Drug Impurities and Reference Standards > Process-Related Standards

Product Description:

Ammonium (S)-5-(4-amino-4-carboxybutanamido)-2-nitrobenzoate, also known as L-ж├-glutamyl-3-carboxy-4-nitroanilide ammonium salt, is a chromogenic substrate specifically designed for the detection and quantification of ж├-glutamyl transferase (GGT) activity. Structurally, it consists of a ж├-glutamyl moiety linked to a 3-carboxy-4-nitroaniline chromophore. Upon enzymatic cleavage by GGT, the free 3-carboxy-4-nitroaniline is released, which can be measured spectrophotometrically at approximately 405 nm. This compound is widely used in clinical diagnostics and biochemical research for liver function tests and the study of glutathione metabolism. It is typically classified as a peptide-like substrate and an amino acid derivative due to its glutamic acid backbone.

Physical Properties

Boiling Point: 718.3 °C at 760 mmHg

Flash Point: 388.2 °C

Solubility: H2O: 100 mg/mL, clear, yellow-green

Storage: 2-8°C