(S)-±-amino-4-methoxybenzenepropanoic acid, CAS No. 6230-11-1

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6230-11-1

Catalog No. EBD339429

CAS 6230-11-1

Name (S)-±-amino-4-methoxybenzenepropanoic acid

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Basic Information

Synonyms: H-Tyr(Me)-OH O-methyltyrosine L-4-Methoxyphenylalanine 4-Methoxy-L-phenylalanine p-Methoxy-L-phenylalanine (S)-±-amino-4-methoxybenzenepropanoicacid (L)-4-Methoxy-phenylalanine O-Methyl-DL-tyrosine L-O-methyltyrosine H-L-Tyr(Me)-OH L-O-methyl-Tyr

Molecular Formula: C10H13NO3

Molecular Weight: 195.22

MDL Number: MFCD00002604

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

P-Methoxy-L-phenylalanine is a non-proteinogenic aromatic amino acid derivative. It features a phenyl ring substituted with a methoxy group at the para position and is the L-enantiomer of this unnatural amino acid. This compound is a white to off-white crystalline powder. Its primary application is in pharmaceutical research and development as a key chiral building block. It is extensively used in the solid-phase peptide synthesis (SPPS) of peptide-based drugs and bioactive peptides. Incorporating this modified phenylalanine can enhance the metabolic stability, bioavailability, and binding affinity of peptide therapeutics by modulating their hydrophobicity and electronic properties. It serves as a crucial intermediate for novel drug candidates. This amino acid derivative is also valuable in biochemical research for studying enzyme-substrate interactions and designing enzyme inhibitors. As a specialty fine chemical, it is typically supplied with high enantiomeric purity for research and development purposes.

Physical Properties

Melting Point: 259-261 °C (dec.)(lit.)

Boiling Point: 350.6 °C at 760 mmHg

Flash Point: 165.8 °C

Density: 1.209 g/cm3

Solubility: Very soluble in water

Storage: 2-8°C

Analytical Data

Appearance: white to very slightly beige powder