4-Iodobenzoic acid, CAS No. 619-58-9

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619-58-9

Catalog No. EBD1820800

CAS 619-58-9

Name 4-Iodobenzoic acid

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Basic Information

Synonyms: 4-Iodobenzoicacid 4-iodobenzoate p-Iodobenzenecarboxylicacid 4-jodbenzoesaeure p-iodobenzoicacid 4-iodobenzoicacid* benzoicacid,4-iodo- benzoicacid,p-iodo- 4-jodbenzoesaeure[german]

Molecular Formula: C7H5IO2

Molecular Weight: 248.02

MDL Number: MFCD00002533

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Basic Synthetic Reagents > Halogenation Reagents

Product Description:

4-Iodobenzoic acid is an aromatic organic compound featuring a carboxylic acid group and an iodine atom in the para position on the benzene ring. It is a white to off-white crystalline powder with a molecular formula of C7H5IO2 and a molecular weight of 248.02 g/mol. It is soluble in organic solvents like ethanol and ether but has limited solubility in water. This compound serves as a versatile and important building block in organic synthesis. The iodine atom is an excellent site for further functionalization via cross-coupling reactions, such as Suzuki, Stille, or Sonogashira couplings, allowing for the introduction of various aryl, alkenyl, or alkynyl groups. The carboxylic acid group can be readily converted into esters, amides, or acid chlorides, or used for direct coupling reactions. Consequently, it is widely employed in the synthesis of pharmaceuticals, liquid crystals, and advanced materials. It can also act as a mild iodinating reagent in specific synthetic contexts. 4-Iodobenzoic acid should be handled with care, avoiding inhalation of dust and contact with skin and eyes. It is generally stable under recommended storage conditions but may decompose upon heating to release toxic fumes, including iodine and carbon oxides.

Physical Properties

Melting Point: 270-273 °C(lit.)

Boiling Point: 318.5 °C at 760 mmHg

Flash Point: 146.4 °C

Density: 2,184 g/cm3

Solubility: 0.04 g/L (25 ºC)

Storage: Store at RT.

Analytical Data

Appearance: white to off-white powder