(S)-(+)-4-bromo-1,2-epoxybutane, CAS No. 61847-07-2

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61847-07-2

Catalog No. EBD551536

CAS 61847-07-2

Name (S)-(+)-4-bromo-1,2-epoxybutane

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Basic Information

Synonyms: (S)-(?-(2-Bromoethyl)oxirane (2S)-2-(2-bromoethyl)oxirane (S)-(+)-4-bromo-1,2-epoxybutane (S)-3,4-Epoxybutylbromide S(-)-4-bromo-1,2-epoxybutane (S)-(-)-4-bromo-1,2-epoxybutane (S)-(-)-(2-bromoethyl)oxirane (S)-4-bromo-1,2-epoxybutane

Molecular Formula: C4H7BrO

Molecular Weight: 151.0

MDL Number: MFCD00042984

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

(S)-(-)-4-Bromo-1,2-epoxybutane is a chiral epoxide compound characterized by a bromine atom at the terminal position. It serves as a versatile and valuable chiral building block in organic synthesis, particularly for the construction of complex molecules with defined stereochemistry. Its primary application is in the pharmaceutical industry as a key chiral intermediate. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs) and their precursors. For instance, it is a crucial starting material for the production of (S)-(-)-1-amino-2-propanol, which is itself an important intermediate for beta-blocker drugs and other pharmacologically active compounds. The chiral epoxide ring allows for regioselective and stereoselective ring-opening reactions with nucleophiles, enabling the efficient introduction of functionalized chiral side chains. This compound is typically handled under inert conditions due to its reactivity and sensitivity to moisture. It is commercially available from suppliers specializing in fine chemicals and chiral intermediates for research and development purposes.

Physical Properties

Boiling Point: 80 °C/50 mmHg(lit.)

Flash Point: 59 °C

Density: 1.521 g/mL at 20 °C(lit.)

Refractivity: n20/D 1.476

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 1993C