17.BETA.-HYDROXY-7.ALPHA.-METHYLESTR-4-EN-3-ONE ACETATE, CAS No. 6157-87-5

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6157-87-5

Catalog No. EBD3069206

CAS 6157-87-5

Name 17.BETA.-HYDROXY-7.ALPHA.-METHYLESTR-4-EN-3-ONE ACETATE

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Basic Information

Synonyms: U-15614 NSC-69948 3-OXO-7WEI-METHYLESTRA-4-ENE-17WEI-OLACETATE 17WEI-HYDROXY-7WEI-METHYLESTR-4-EN-3-ONEACETATE ACETICACID3-OXO-7WEI-METHYLESTRA-4-ENE-17WEI-YLESTER 17.BETA.-HYDROXY-7.ALPHA.-METHYLESTR-4-EN-3-ONEACETATE trestoloneacetate Trestoloneacetate[USAN] 17beta-Hydroxy-7alpha-methylestr-4-en-3-oneacetate 19-Nortestosterone,7alpha-methyl-,acetate CDB903 NSC69948 Orgasteronacetate U-15,614 UNII-52XDF4N1XL Estr-4-en-3-one,17-(acetyloxy)-7-methyl-,(7alpha,17beta)- Estr-4-en-3-one,17beta-hydroxy-7alpha-methyl-,acetate(8CI) (7alpha,8xi,10xi,13xi,17beta)-7-methyl-3-oxoestr-4-en-17-ylacetate (7alpha,10xi,17beta)-7-methyl-3-oxoestr-4-en-17-ylacetate 7-methyl-3-oxoestr-4-en-17-ylacetate

Molecular Formula: C21H30O3

Molecular Weight: 330.46

Categories: Medicinal Chemistry > APIs and Their Salts > Endocrine & Metabolic Drugs Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Treosulfan, also known as L-threitol 1,4-bismethanesulfonate, is a bifunctional alkylating agent. It is a prodrug that undergoes non-enzymatic conversion in vivo to its active epoxide forms, which exert cytotoxic effects by cross-linking DNA strands, thereby inhibiting DNA synthesis and cell division. Primarily, treosulfan is used as a chemotherapeutic agent, particularly in the treatment of ovarian cancer. Its major application, however, is in the field of hematopoietic stem cell transplantation (HSCT). It is used as a conditioning agent prior to transplantation due to its potent myeloablative and immunosuppressive properties. Treosulfan-based conditioning regimens are considered an alternative to busulfan, especially for patients who may not tolerate high doses of busulfan or total body irradiation. The compound is characterized by its relatively favorable toxicity profile compared to some other alkylating agents, with potentially reduced incidences of severe organ toxicity, such as veno-occlusive disease of the liver. It is typically administered intravenously.

Physical Properties

Boiling Point: 447.571 °C at 760 mmHg

Flash Point: 194.228 °C

Density: 1.117 g/cm3