alpha,alpha-trehalose dihydrate, CAS No. 6138-23-4

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6138-23-4

Catalog No. EBD2205413

CAS 6138-23-4

Name alpha,alpha-trehalose dihydrate

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Basic Information

Synonyms: D-(+)-trehalosedihydrate alpha,alpha-trehalosedihydrate D(+)-Trehalosedihydrate D-Trehalose,dihydrate alpha,alpha-D-Trehalosedihydrate alpha-D-Glucopyranosyl-alpha-D-glucopyranosidedihydrate D(+)trehalosedihydratecell*culturetested D(+)trehalosedihydrate D(+)trehalosereducedmetalioncontentdihydrate L-TrehaloseDihydrate

Molecular Formula: C12H26O13

Molecular Weight: 378.33

MDL Number: MFCD00071594

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Excipients > Novel and Functional Excipients

Product Description:

D-(+)-Trehalose dihydrate is a non-reducing disaccharide composed of two glucose molecules linked by an α,α-1,1-glycosidic bond. It exists as a stable crystalline dihydrate. This unique structure endows it with exceptional stability and protective properties. Its primary and most significant application is in the biopharmaceutical and life sciences industries as a superior cryoprotectant and stabilizer. Trehalose is widely used to protect proteins, vaccines, enzymes, antibodies, and other biologics during lyophilization (freeze-drying), storage, and transportation. It stabilizes biomolecules by forming a glassy matrix that replaces water molecules, preventing denaturation and aggregation. This makes it a crucial **functional excipient** in advanced drug formulations. Furthermore, it serves as an important carbohydrate source and stress protectant in cell culture media and various biochemical assays. Beyond pharmaceuticals, trehalose finds use as a food additive (humectant, texturizer, and shelf-life extender) and in cosmetics for its moisturizing properties. It is generally recognized as safe (GRAS).

Physical Properties

Melting Point: 97-99 °C(lit.)

Boiling Point: 675.4 °C at 760 mmHg

Flash Point: 362.3 °C

Density: 1.76 g/cm3

Solubility: H2O: 50 mg/mL

Refractivity: 181 ° (C=7, H2O)

Storage: Store at RT.

Analytical Data

Appearance: white to off-white crystalline powder