AmoxicillinTrihydrate, CAS No. 61336-70-7

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61336-70-7

Catalog No. EBD2199149

CAS 61336-70-7

Name AmoxicillinTrihydrate

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Basic Information

Synonyms: Amoxycillintrihydrate D-(-)-alpha-amino-p-hydroxybenzylpenicillintrihydrate (2S,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-,trihydrate,(2s-(2-alpha,5-alpha,6-beta4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid AmoxicillineTrihydrate AmoxycillineTrihydrate (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacidtrihydrate

Molecular Formula: C16H21N3O6S

Molecular Weight: 383.42

MDL Number: MFCD00072029

Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Amoxicillin trihydrate is a broad-spectrum, semisynthetic beta-lactam antibiotic belonging to the aminopenicillin class. It is the trihydrate form of amoxicillin, a white to off-white crystalline powder with the molecular formula C₁₆H₁₉N₃O₅S·3H₂O. Its chemical structure features a beta-lactam ring fused to a thiazolidine ring, with an amino group at the 6-position, which contributes to its activity against both Gram-positive and Gram-negative bacteria. As an active pharmaceutical ingredient (API), its primary and dominant application is in the treatment of various bacterial infections. It works by inhibiting the synthesis of bacterial cell walls, leading to cell lysis and death. It is widely formulated into oral dosage forms (capsules, tablets, suspensions) for infections of the respiratory tract, ear, nose, throat, skin, and urinary tract. It is also commonly used in combination with a beta-lactamase inhibitor (e.g., clavulanic acid) to overcome bacterial resistance. Amoxicillin trihydrate is one of the most commonly prescribed antibiotics globally. It is listed on the World Health Organization's List of Essential Medicines. Key considerations in its handling and formulation include its stability, which is affected by moisture and temperature, and its potential to cause allergic reactions in individuals sensitive to penicillins.

Physical Properties

Boiling Point: 743.2 °C at 760 mmHg

Flash Point: 403.3 °C

Refractivity: 302 ° (C=0.1, H2O)

Storage: 2-8°C

Analytical Data

Appearance: A White CRYSTALLINE powder