D-Glucaro-1,4-lactone monohydrate, CAS No. 61278-30-6

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61278-30-6

Catalog No. EBD3064074

CAS 61278-30-6

Name D-Glucaro-1,4-lactone monohydrate

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Basic Information

Synonyms: D-GLUCARIDACID-1,4-LACTONE D-GLUCARICACID-1,4-LACTONE D-GLUCARO-1,4-LACTONEMONOHYDRATE 1,4-LACTONE-D-GLUCARICACIDMONOHYDRATE D-SACCHARICACID1,4-LACTONEMONOHYDRATE D-SACCHARICACID1,4-LACTONEORMONOHYDRATE D-GLUCARICACID-1,4-LACTONEMONOHYDRATE,98% D-GLUCARICACID-1,4-LACTONE,D-SACCHAROLACTONE D-SACCHARICACID1,4-LACTONEMONOHYDRATE,D-GLUCARICACID-1,4-LACTONE,D-SACCHAROLACTONE D-SACCHARICACID14-LACTONE (2S)-2-[(2S,4R)-3,4-dihydroxy-5-oxo-tetrahydrofuran-2-yl]-2-hydroxy-aceticacidhydrate

Molecular Formula: C6H10O8

Molecular Weight: 210.14

Categories: Medicinal Chemistry > Pharmaceutical Excipients > Disintegrants Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

D-Glucaro-1,4-lactone is a derivative of glucaric acid, specifically the 1,4-lactone form. It is a white to off-white crystalline powder that is soluble in water. This compound is a naturally occurring substance found in small amounts in various fruits and vegetables. Its primary and well-established application is in the pharmaceutical industry as a tablet disintegrant. It functions by rapidly absorbing water and swelling upon contact with aqueous media, thereby promoting the rapid breakup of tablets and enhancing drug dissolution. This property makes it a valuable excipient in oral solid dosage formulations. Additionally, D-glucaro-1,4-lactone is of significant interest in biochemical and nutritional research. It is a potent inhibitor of β-glucuronidase, an enzyme involved in the enterohepatic circulation of various compounds, including toxins, hormones, and drugs. This inhibitory activity underpins its investigation for potential roles in chemoprevention and detoxification. While it serves as a biochemical tool and a precursor in carbohydrate chemistry, its defined and significant use as a pharmaceutical excipient (disintegrant) is the dominant factor for its primary classification.

Physical Properties

Melting Point: 80-82°C

Storage: 2-8°C