S-(-)-3-amino-1,2-propanediol, CAS No. 61278-21-5

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61278-21-5

Catalog No. EBD2205260

CAS 61278-21-5

Name S-(-)-3-amino-1,2-propanediol

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Basic Information

Synonyms: (S)-3-amino-1,2-propanediole S-(-)-3-amino-1,2-propanediol (S)-3-Amino-1,2-propanediol (2S)-3-Aminopropane-1,2-diol 1,2-Propanediol,3-amino-,(2S)- Amino-1,2-propanediol,(S)-3- (S)-(-)-3-Amino-1,2-propanediol

Molecular Formula: C3H9NO2

Molecular Weight: 9111.0

MDL Number: MFCD00798260

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-3-Amino-1,2-propanediol is a chiral amino alcohol characterized by a primary amine and two hydroxyl groups on a three-carbon backbone. Its (S)-configuration makes it a valuable chiral building block in asymmetric synthesis. This compound serves as a crucial intermediate in the pharmaceutical industry. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs), including antiviral drugs and other therapeutic agents where its chiral 1,2-amino alcohol moiety is a key structural motif. Its applications extend to the preparation of chiral ligands for catalysis and as a precursor for functionalized polymers and surfactants. Handling requires standard precautions for amino alcohols, including the use of personal protective equipment due to its potential for skin and eye irritation. It is typically stored in a cool, dry place under inert atmosphere to maintain stability.

Physical Properties

Melting Point: 54-56°C

Boiling Point: 117-119 °C/0.4 mmHg(lit.)

Flash Point: 113 °C

Density: 1.175 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.483(lit.)

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3259PSN1