(S)-Benzyl 3-methylpiperazine-1-carboxylate, CAS No. 612493-87-5

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612493-87-5

Catalog No. EBD2210945

CAS 612493-87-5

Name (S)-Benzyl 3-methylpiperazine-1-carboxylate

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Basic Information

Synonyms: (S)-Benzyl3-methylpiperazine-1-carboxylate 4-Cbz-(S)-2-Methylpiperazine 4-N-Benzoxycarbonyl-2-(S)-Methylpiperazine 1-Cbz-(S)-3-Methylpiperazine (S)-1-Carbobenzyloxy-3-Methylpiperazine (S)-4-CBZ-2-Methylpiperazine (3S)-1-Benzyloxycarbonyl-3-methylpiperazine (S)-4-Benzoxycarbonyl-2-methylpiperazine

Molecular Formula: C13H18N2O2

Molecular Weight: 234.29

MDL Number: MFCD04039319

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-4-Cbz-2-Methylpiperazine is a chiral piperazine derivative featuring a carboxybenzyl (Cbz) protecting group on the nitrogen at the 4-position and a methyl substituent at the 2-position. This specific stereochemistry (S-configuration) is crucial for its application in asymmetric synthesis. This compound is primarily employed as a key chiral building block and intermediate in pharmaceutical research and development. Its piperazine core is a privileged scaffold found in numerous bioactive molecules, particularly in central nervous system (CNS) agents and other therapeutic areas. The Cbz group serves as a standard nitrogen-protecting group, allowing for selective deprotection and further functionalization during multi-step synthetic sequences. As a versatile chiral amine synthon, it is used to introduce the (S)-2-methylpiperazine moiety into target drug candidates. Its availability in enantiomerically pure form makes it valuable for constructing molecules with defined stereochemistry, which is often essential for biological activity and drug efficacy.

Physical Properties

Boiling Point: 358 °C at 760 mmHg

Flash Point: 170.3 °C

Density: 1.105 g/cm3