Linocaine hydrochloride hydrate, CAS No. 6108-05-0

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6108-05-0

Catalog No. EBD33165

CAS 6108-05-0

Name Linocaine hydrochloride hydrate

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Basic Information

Synonyms: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamidehydrochloridehydrate Linocainehydrochloridehydrate Lidocainehydrochloridemonohydrate LIDOCAINEHCLmonohydrate 2-[(2,6-dimethylphenyl)amino]-N,N-diethyl-2-oxoethanaminiumchloridehydrate(1:1:1) LinocaineHydrochloride

Molecular Formula: C14H25ClN2O2

Molecular Weight: 288.81

MDL Number: MFCD00034865

Categories: Medicinal Chemistry > APIs and Their Salts > Anesthetics and Analgesics

Product Description:

Lidocaine hydrochloride monohydrate is the monohydrate salt form of lidocaine hydrochloride. It is a white or almost white, crystalline powder that is freely soluble in water and soluble in alcohol. Chemically, it is 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, belonging to the class of amino amide local anesthetics. This compound functions as a sodium channel blocker. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby producing local anesthetic and antiarrhythmic effects. Its primary and definitive application is as an active pharmaceutical ingredient (API) in injectable formulations for local anesthesia and regional nerve blocks in medical and dental procedures. It is also used intravenously as an antiarrhythmic agent to treat ventricular tachycardia. The monohydrate form is often specified in pharmacopeial standards (e.g., USP, Ph. Eur.) to ensure consistent quality, stability, and performance in pharmaceutical manufacturing. It is a well-established and critical drug substance with no significant role as a general-purpose synthetic building block in research chemistry.

Physical Properties

Boiling Point: 350.8 °C at 760 mmHg

Flash Point: 166 °C

Solubility: H2O: soluble

Safety Information

Packing Level: III

Hazard Category: 6.1

Transport Codes: 2811

Analytical Data

Appearance: white solid