Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    610309-89-2

    Catalog No. EBD21971

    CAS 610309-89-2

    Name Carvedilol phosphate hemihydrate

    Get Quote
    Basic Information

    Synonyms: CarvedilolPhosphate 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-olphosphatehydrate(2:2:1) 1-(9H-Carbozol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanolphosphatehydrate(2:2:1) Carvedilolphosphatehemihydrate

    Molecular Formula: C48H60N4O17P2

    Molecular Weight: 1026.95

    Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    Carvedilol phosphate is a phosphate salt of carvedilol, a non-selective beta-adrenergic blocker with alpha-1 blocking activity. This salt form is developed to improve the physicochemical properties, such as solubility and stability, of the parent drug carvedilol, potentially enhancing its bioavailability and formulation characteristics. Carvedilol phosphate is primarily used as an active pharmaceutical ingredient (API) for the treatment of cardiovascular diseases, specifically hypertension and chronic heart failure. Its mechanism involves blocking both beta-1, beta-2, and alpha-1 adrenergic receptors, leading to vasodilation and reduced cardiac workload. It also finds application in the management of certain neurological conditions, such as essential tremor, due to its beta-blocking properties. The development of carvedilol phosphate represents a pharmaceutical strategy to create improved dosage forms, such as immediate-release or controlled-release tablets, offering potential therapeutic advantages over the free base. As a salt of a well-established drug, its safety profile is closely related to that of carvedilol, with common side effects including dizziness, fatigue, and hypotension.
    Physical Properties

    Boiling Point: 655.2 °C at 760 mmHg

    Flash Point: 350.1 °C

    mg g kg ml l t